RAD-140 (Testolone): FDA Status, Half-Life & Safety
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RAD-140 (Testolone): FDA status, half-life and safety

Doses studied · Approval status · Half-life ~45 hours

Short answer: RAD-140 has a half-life of about 45 hours. People vary, so treat these as estimates.

What is RAD-140?

RAD-140 (testolone) is an oral selective androgen receptor modulator (SARM), a non-steroidal compound developed by Radius Health to act on androgen receptors. It has been tested in people only in one small cancer trial and is not FDA approved.

Also known as: RAD140, Testolone.

Doses studied

There is no approved product. The only published human trial gave 50, 100 or 150 mg once a day to 22 women with advanced breast cancer, and found 100 mg a day was the highest dose they tolerated (LoRusso 2022). It was not a trial in healthy people or for muscle. These are trial protocols, not personalized advice; confirm any dosing with your prescriber.

Approval status and how it is used

RAD-140 is not FDA approved; it is an investigational drug. FDA says SARMs are unapproved drugs that cannot be legally marketed in the US as dietary supplements or drugs, and lists risks including liver injury and acute liver failure, a higher risk of heart attack or stroke, and effects on fertility. The World Anti-Doping Agency (WADA) names it on its 2026 Prohibited List as a SARM under "other anabolic agents" (S1.2), banned in and out of competition.

Its developers described it in 2011 as a potent SARM taken by mouth, tested in animal models (Miller 2011). In the first human trial (LoRusso 2022), in women with heavily treated metastatic breast cancer, the most common side effects were raised liver enzymes (AST in 59% and ALT in 45% of patients) and raised bilirubin, plus vomiting, dehydration, and less appetite and weight. 16 of 22 patients had a grade 3 or 4 side effect.

Outside trials, doctors have reported liver injury in people who took RAD-140 bought as a supplement. In one case (Leung 2022), a 24-year-old man developed jaundice after 5 weeks of RAD-140; it got better after he stopped.

RAD-140 half-life and time to peak

  • Half-lifeabout 45 hours
  • Time to peak (Tmax)Not listed

In the first human trial (LoRusso 2022), RAD-140 had a half-life of 44.7 hours, which the authors said supported once-daily dosing. That trial was in women with advanced breast cancer, not healthy people. The paper's summary gives no time to peak, so we do not list one.

Numbers shown are taken from the source above. Half-life varies from person to person.

How to track RAD-140 in Dose Track

  1. Add RAD-140 as a custom compound. Start typing its name and Dose Track fills in the details from its research library for you to check, and it sits next to everything else you take.
  2. Log each tablet when you take it, including split or fractional tablets, so your history shows exactly what you took and when.
  3. Set reminders on your own schedule, whether that is daily, weekly or every few days.
  4. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

How Dose Track handles peptides · Reconstitution calculator · Half-life calculator

Ligandrol (LGD-4033)LGD-4033, VK5211 · half-life about 30 hours Ostarine (Enobosarm)enobosarm, MK-2866 S-23S23 Andarine (S-4)S-4, S4

Frequently asked questions

What is the half-life of RAD-140?+
In the first human trial (LoRusso 2022), RAD-140 had a half-life of 44.7 hours, which the authors said supported once-daily dosing. That trial was in women with advanced breast cancer, not healthy people. The paper's summary gives no time to peak, so we do not list one.
Is RAD-140 legal?+
It is not FDA approved. FDA says SARMs cannot be legally marketed in the US as dietary supplements or drugs, and WADA bans RAD140 in sport at all times.
Has RAD-140 been tested in people?+
In one published phase 1 trial, in 22 women with advanced breast cancer (LoRusso 2022). Raised liver enzymes were the most common side effect. There is no published trial in healthy people.
Can I track RAD-140 in Dose Track?+
Yes. RAD-140 is in Dose Track's research library, so when you add it as a custom compound its details are filled in for you to check. You can then log each tablet next to your other compounds, set reminders on your own schedule, and see your history next to your lab results. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

Sources

  1. LoRusso P, et al. A first-in-human phase 1 study of a novel selective androgen receptor modulator (SARM), RAD140, in ER+/HER2- metastatic breast cancer. Clin Breast Cancer. 2022;22(1):67-77.
  2. FDA Consumer Update. FDA warns of use of selective androgen receptor modulators (SARMs) among teens, young adults (April 2023).
  3. World Anti-Doping Agency. 2026 Prohibited List (S1.2 other anabolic agents; S2.2.1; S4.4.1 metabolic modulators; S6 stimulants).
  4. Miller CP, et al. Design, synthesis, and preclinical characterization of the selective androgen receptor modulator (SARM) RAD140. ACS Med Chem Lett. 2011;2(2):124-129.
  5. Leung K, et al. RAD-140 drug-induced liver injury. Ochsner J. 2022;22(4):361-365.

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