Short answer: Pramiracetam has a half-life of about 4.5 to 6.5 hours. Levels peak about 2 to 3 hours after a dose. People vary, so treat these as estimates.
Pramiracetam is a synthetic "racetam" drug related to piracetam, developed in the 1980s for memory problems. It is not approved by FDA in the US.
Also known as: racetam, Pramistar.
There is no FDA-approved pramiracetam product. A head injury trial used 400 mg three times a day (McLean 1991); a safety study gave single doses of 400 to 1,600 mg (Chang 1985). These are study protocols, not a recommendation.
Pramiracetam is not FDA approved: we found no pramiracetam product in Drugs@FDA. In a 2023 debarment order, FDA described a seller of "nootropics" whose imported products, including pramiracetam, FDA had identified as unapproved new drugs and misbranded drugs (Federal Register 2023).
What studies show: evidence is very limited. In a small placebo-controlled study of young men with memory problems after head injury or lack of oxygen, 400 mg three times a day improved memory measures, especially delayed recall (McLean 1991). We found no recent large trials.
Safety: no significant side effects were seen with single doses up to 1,600 mg in 12 healthy men (Chang 1985). Products sold online as nootropics are not checked by FDA for content or purity.
In 12 healthy men given single doses of 400 to 1,600 mg after an overnight fast, pramiracetam peaked 2 to 3 hours after the dose and had an elimination half-life of 4.5 to 6.5 hours, regardless of dose (Chang 1985). This is one small 1985 study; there is no FDA label to check against.
Numbers shown are taken from the source above. Half-life varies from person to person.
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