Short answer: Ospemifene has a half-life of about 26 hours. Levels peak about 2 hours (1 to 8 hours) after a dose. People vary, so treat these as estimates.
Ospemifene is an estrogen agonist/antagonist taken by mouth. It acts like estrogen on the vaginal lining and the uterine lining but can act differently in other tissues. It is sold as Osphena (Duchesnay) for vaginal symptoms after menopause.
Also known as: Osphena.
Osphena comes as a single 60 mg tablet strength, taken once a day with food.
The Osphena label approves ospemifene for moderate to severe pain during sex (dyspareunia) and moderate to severe vaginal dryness, both from vaginal atrophy due to menopause. Label dosing is 60 mg once a day with food, for the shortest time that meets the goal, with periodic checks.
Its boxed warning is titled "Endometrial cancer and cardiovascular disorders": it acts like estrogen in the uterine lining, so unexplained bleeding is checked, and its trials reported stroke and blood clot rates alongside the Women's Health Initiative findings. It is not used with unexplained genital bleeding, estrogen-dependent cancer, a current or past blood clot, stroke or heart attack, or pregnancy, and not with estrogens or other estrogen agonist/antagonists. In 12-week trials, hot flush was 6.5% vs 2.6% on placebo and vaginal discharge 3.8% vs 0.4%. Full numbers are on the Osphena side effects and Osphena dosing schedule pages. Comparisons: Osphena vs Intrarosa and Osphena vs Vagifem.
The Osphena label says levels peak at a median of about 2 hours (range 1 to 8) after a 60 mg tablet, and the apparent terminal half-life in women after menopause is about 26 hours. Food did not change the half-life or time to peak.
Numbers shown are taken from the source above. Half-life varies from person to person.
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