Oleoylethanolamide (OEA): Weight and Metabolic Data
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Oleoylethanolamide (OEA): half-life, strengths and approval status

Amounts studied · Approval status · Half-life notes

What is oleoylethanolamide?

Oleoylethanolamide (OEA) is a lipid the body makes naturally, described as endocannabinoid-like. As a supplement it has been studied for weight, appetite and metabolic health.

Also known as: OEA.

Amounts studied

An 8-week trial used 125 mg twice a day (Ostadrahimi 2024). These are study protocols, not a recommendation.

Approval status and how it is used

It is sold in the US as a dietary supplement. Under the 1994 dietary supplement law (DSHEA), FDA does not approve dietary supplements before they are marketed, and the maker, not FDA, is responsible for safety and labeling. It is not an FDA-approved weight-loss drug.

What studies show: a 2025 meta-analysis of 10 trials found OEA improved weight, BMI, waist size, fat mass, triglycerides, blood sugar, insulin and some inflammation markers, but not cholesterol, HbA1c or fat-free mass; the authors said more research is needed before firm conclusions (Bahari 2025). In an 8-week placebo-controlled trial in 60 adults with obesity, 125 mg twice a day lowered triglycerides (from about 166 to 142 mg/dL), with no change in cholesterol, blood sugar or eating habits (Ostadrahimi 2024).

Safety: the sources here do not describe side effects or drug interactions.

Oleoylethanolamide half-life and time to peak

  • Half-lifeNot listed
  • Time to peak (Tmax)Not listed

We could not find a single published half-life or time to peak for OEA that applies to a supplement dose, so we do not list one.

How to track oleoylethanolamide in Dose Track

  1. Add oleoylethanolamide as a custom compound. Start typing its name and Dose Track fills in the details from its research library for you to check, and it sits next to everything else you take.
  2. Log each dose when you take it so your history shows exactly what you took and when.
  3. Set reminders on your own schedule, whether that is daily, weekly or every few days.
  4. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

How Dose Track handles peptides · Reconstitution calculator · Half-life calculator

Palmitoylethanolamide (PEA)PEA, palmidrol Berberineberberine HCl, berberine chloride · half-life about 30.6 hours Conjugated Linoleic Acid (CLA)CLA

Frequently asked questions

What is the half-life of oleoylethanolamide?+
We could not find a single published half-life or time to peak for OEA that applies to a supplement dose, so we do not list one.
Does OEA help weight loss?+
A 2025 meta-analysis of 10 small trials found modest improvements in weight and waist size, and the authors called for more research. OEA is not an approved weight-loss medicine.
Can I track oleoylethanolamide in Dose Track?+
Yes. Oleoylethanolamide is in Dose Track's research library, so when you add it as a custom compound its details are filled in for you to check. You can then log each dose next to your other compounds, set reminders on your own schedule, and see your history next to your lab results. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

Sources

  1. Bahari H, et al. Oleoylethanolamide supplementation on cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials. Front Nutr. 2025;12:1553288.
  2. Ostadrahimi A, et al. The effect of oleoylethanolamide supplementation on lipid profile, fasting blood sugar and dietary habits in obese people: a randomized double-blind placebo-control trial. BMC Endocr Disord. 2024.
  3. FDA. Questions and answers on dietary supplements.

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