Octopamine is a stimulant amine closely related to synephrine, found in small amounts in bitter orange and in some invertebrates. It is added to some weight-loss and pre-workout products.
Also known as: p-octopamine, norsynephrine, norsympathol, beta-hydroxytyramine.
We found no trials of octopamine supplements in people, so there is no studied amount to list. Testing has found it in US sports and bitter orange supplements (Zhao 2018, Pawar 2020).
WADA's 2026 Prohibited List names octopamine under S6.B, specified stimulants, prohibited in competition. FDA's dietary supplement ingredient directory lists it as a new dietary ingredient that requires a premarket safety notification, for which none has been submitted, and links a May 2022 warning letter to a seller (FDA).
What is known: testing of US supplements has found octopamine in sports products (Zhao 2018) and in bitter orange products (Pawar 2020). In a doping-control study, urine octopamine rose sharply after a medicine containing octopamine, but not after synephrine or the dietary supplements tested, so synephrine itself did not appear to cause a positive octopamine test (Thevis 2012).
We found no trials of octopamine in people, so its effects and safety at supplement amounts are not known. Athletes subject to drug testing should treat it as a banned substance.
We could not find a single published half-life or time to peak for octopamine that applies to a supplement dose, so we do not list one.
How Dose Track handles peptides · Reconstitution calculator · Half-life calculator