NMN (Nicotinamide Mononucleotide): FDA Status, Trials
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NMN (Nicotinamide Mononucleotide): half-life, strengths and approval status

Amounts studied · Approval status · Half-life notes

What is NMN?

NMN (nicotinamide mononucleotide) is a niacin-like compound that the body uses to make NAD, a coenzyme cells need for energy metabolism. It is one step closer to NAD than nicotinamide riboside (NR).

Also known as: nicotinamide mononucleotide, beta-NMN, β-NMN.

Amounts studied

NMN has no intake value or upper limit. Trials used 125 mg twice a day for 12 weeks (Katayoshi 2023) and 300, 600 or 900 mg once a day for 60 days (Yi 2023). These are study protocols, not a recommendation.

Approval status and how it is used

NMN's legal status changed. The NIH Office of Dietary Supplements niacin fact sheet (updated November 2022) says NMN and nicotinamide riboside are sold as dietary supplements but are not labeled as sources of niacin, and that FDA ruled in November 2022 that NMN could not be sold as a supplement because it had been authorized for study as a new drug. In a December 2, 2025 letter, FDA wrote that on September 29, 2025 it changed its reading of the law and determined that NMN is not excluded from the dietary supplement definition, and it set aside its November 2022 letter. Under the 1994 dietary supplement law (DSHEA), FDA does not approve dietary supplements before they are marketed.

What studies show: in a 60-day trial of 80 healthy middle-aged adults, all three NMN amounts raised blood NAD compared with placebo, highest at 600 and 900 mg; walking distance in a 6-minute test rose more than on placebo, insulin resistance (HOMA-IR) did not change, and no safety issues were found (Yi 2023). In a 10-week trial in postmenopausal women with prediabetes and overweight or obesity, muscle insulin sensitivity rose after NMN but not after placebo (Yoshino 2021). In a 12-week trial of 36 healthy middle-aged people, 250 mg a day raised serum nicotinamide, arterial stiffness tended to fall but did not differ from placebo, and there were no adverse events (Katayoshi 2023).

See the oral NAD+ page for NR and NMN together, and nicotinamide riboside on its own.

NMN half-life and time to peak

  • Half-lifeNot listed
  • Time to peak (Tmax)Not listed

We could not find a single published half-life or time to peak for NMN that applies to a supplement dose, so we do not list one. The trials here measured blood NAD and related compounds, not NMN itself.

How to track NMN in Dose Track

  1. Add NMN as a custom compound. Start typing its name and Dose Track fills in the details from its research library for you to check, and it sits next to everything else you take.
  2. Log each dose when you take it so your history shows exactly what you took and when.
  3. Set reminders on your own schedule, whether that is daily, weekly or every few days.
  4. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

How Dose Track handles peptides · Reconstitution calculator · Half-life calculator

Oral NAD+ Precursors (NR and NMN)nicotinamide riboside, NR Nicotinamide Riboside (NR)NR, nicotinamide riboside chloride NAD+ (injectable)nicotinamide adenine dinucleotide Niacinamide (Nicotinamide)nicotinamide, vitamin B3

Frequently asked questions

What is the half-life of NMN?+
We could not find a single published half-life or time to peak for NMN that applies to a supplement dose, so we do not list one. The trials here measured blood NAD and related compounds, not NMN itself.
Is NMN legal as a dietary supplement?+
FDA said in 2022 that NMN was excluded from the dietary supplement definition because it had been studied as a drug. In a December 2025 letter, FDA said it had changed its view on September 29, 2025 and that NMN is not excluded from the definition.
Does NMN raise NAD levels?+
In a 60-day trial of 80 healthy adults, 300, 600 and 900 mg a day all raised blood NAD compared with placebo, with the highest levels at 600 and 900 mg.
Can I track NMN in Dose Track?+
Yes. NMN is in Dose Track's research library, so when you add it as a custom compound its details are filled in for you to check. You can then log each dose next to your other compounds, set reminders on your own schedule, and see your history next to your lab results. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

Sources

  1. FDA, Human Foods Program. Reinstatement response letter to Willy Nutra, Inc. regarding NDI 1234, beta-nicotinamide mononucleotide (NMN), December 2, 2025. Regulations.gov FDA-2022-S-0023-0066.
  2. NIH Office of Dietary Supplements. Niacin: fact sheet for health professionals (updated November 18, 2022).
  3. Yi L, et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience. 2023;45(1):29-43.
  4. Yoshino M, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229.
  5. Katayoshi T, et al. Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial. Sci Rep. 2023;13(1):2786.

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