MCHC (Ossein-Hydroxyapatite): Bone Density Trials
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Microcrystalline Hydroxyapatite (MCHC): half-life, strengths and approval status

Amounts studied · Approval status · Half-life notes

What is Hydroxyapatite (MCHC)?

Microcrystalline hydroxyapatite (MCHC), studied as ossein-hydroxyapatite complex (OHC), is a calcium supplement made from bone, compared in trials with plain calcium carbonate.

Also known as: MCHC, ossein-hydroxyapatite complex, OHC, microcrystalline hydroxyapatite, bone meal calcium.

Amounts studied

Trials used 3.32 g a day for 2 years (Castelo-Branco 1999) and 1,660 mg a day for 6 months (Castelo-Branco 2015). These are study protocols, not a recommendation.

Approval status and how it is used

It is sold in the US as a dietary supplement. Under the 1994 dietary supplement law (DSHEA), FDA does not approve dietary supplements before they are marketed, and the maker, not FDA, is responsible for safety and labeling.

What studies show: a 2009 meta-analysis of 6 trials found bone density changed about 1 percentage point more favorably with OHC than with calcium carbonate (Castelo-Branco 2009). In an open 2-year study in 60 postmenopausal women, bone density held steady on OHC but fell on calcium carbonate in year 2 and in untreated women (Castelo-Branco 1999). In 74 perimenopausal women with low bone mass, 6 months of OHC eased back and knee pain more than calcium carbonate (Castelo-Branco 2015). These studies were open-label (not blinded) and share the same lead author, so independent trials would help.

Safety: the sources here do not report safety problems. The sources here do not describe drug interactions.

Hydroxyapatite (MCHC) half-life and time to peak

  • Half-lifeNot listed
  • Time to peak (Tmax)Not listed

We could not find a single published half-life or time to peak for MCHC that applies to a supplement dose, so we do not list one.

How to track Hydroxyapatite (MCHC) in Dose Track

  1. Add Hydroxyapatite (MCHC) as a custom compound. Start typing its name and Dose Track fills in the details from its research library for you to check, and it sits next to everything else you take.
  2. Log each dose when you take it so your history shows exactly what you took and when.
  3. Set reminders on your own schedule, whether that is daily, weekly or every few days.
  4. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

How Dose Track handles peptides · Reconstitution calculator · Half-life calculator

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Frequently asked questions

What is the half-life of Hydroxyapatite (MCHC)?+
We could not find a single published half-life or time to peak for MCHC that applies to a supplement dose, so we do not list one.
Is MCHC better than calcium carbonate?+
A 2009 meta-analysis of 6 trials found about 1 percentage point better bone density change with OHC. The trials were small and mostly not blinded.
Can I track Hydroxyapatite (MCHC) in Dose Track?+
Yes. Hydroxyapatite (MCHC) is in Dose Track's research library, so when you add it as a custom compound its details are filled in for you to check. You can then log each dose next to your other compounds, set reminders on your own schedule, and see your history next to your lab results. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

Sources

  1. Castelo-Branco C, et al. Efficacy of ossein-hydroxyapatite complex compared with calcium carbonate to prevent bone loss: a meta-analysis. Menopause. 2009;16(5):984-991.
  2. Castelo-Branco C, et al. Preventing postmenopausal bone loss with ossein-hydroxyapatite compounds: results of a two-year, prospective trial. J Reprod Med. 1999;44(7):601-605.
  3. Castelo-Branco C, et al. Comparison of the effects of calcium carbonate and ossein-hydroxyapatite complex on back and knee pain and quality of life in osteopenic perimenopausal women. Maturitas. 2015;81(1):76-82.
  4. FDA. Questions and answers on dietary supplements.

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