Hesperidin is a flavanone, a plant compound found mainly in citrus fruits, studied as a supplement for heart and metabolic health. On its own it does not appear to help weight loss: a meta-analysis of 11 trials found no effect on body weight, BMI, fat mass or waist size.
Also known as: glucosyl hesperidin, G-hesperidin.
A 12-week Japanese trial used 500 mg a day of glucosyl hesperidin with or without 25, 50 or 75 mg of caffeine (Ohara 2016). A 2025 meta-analysis found lipid and blood sugar effects mainly above 500 mg a day (Heidari 2025). These are study protocols, not a recommendation.
It is sold in the US as a dietary supplement. Under the 1994 dietary supplement law (DSHEA), FDA does not approve dietary supplements before they are marketed, and the maker, not FDA, is responsible for safety and labeling.
What studies show: a 2021 meta-analysis of 11 trials (512 people) found that hesperidin or orange juice had no significant effect on body weight, BMI, fat mass, body fat percentage or waist size (Djafari 2021). A 2025 meta-analysis found lower fasting blood sugar, triglycerides, total and LDL cholesterol, and systolic blood pressure, with no change in insulin, insulin resistance, HDL or diastolic pressure (Heidari 2025). In a 12-week trial in 75 adults with overweight, glucosyl hesperidin plus 50 or 75 mg of caffeine reduced belly fat compared with placebo, while hesperidin alone or with 25 mg of caffeine did not; ODS says this suggests the higher caffeine amounts may be responsible (Ohara 2016). The authors of that trial worked for House Wellness Foods, a Japanese food company.
Safety: the sources here do not describe side effects or drug interactions for hesperidin.
We could not find a single published half-life or time to peak for hesperidin that applies to a supplement dose, so we do not list one.
How Dose Track handles peptides · Reconstitution calculator · Half-life calculator