DMAE (Deanol): Old Trials, Skin Use, Evidence | Dose Track
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DMAE (Deanol): half-life, strengths and approval status

Amounts studied · Approval status · Half-life notes

What is DMAE?

DMAE (deanol, or dimethylaminoethanol) is a small molecule related to choline. It has been taken by mouth for attention and memory and is added to anti-aging skin creams.

Also known as: deanol, dimethylaminoethanol, 2-dimethylaminoethanol.

Amounts studied

A 1975 trial in children used 500 mg a day for 3 months (Lewis 1975). These are study protocols, not a recommendation.

Approval status and how it is used

DMAE is sold in products labeled as supplements and in skin creams. Its effects in people have not been well studied.

What studies show: in a 3-month 1975 trial in 74 children with learning and behavior problems, deanol 500 mg a day and methylphenidate both improved some test scores compared with placebo; the authors said how deanol works is unclear and called for more studies (Lewis 1975). A 2018 Cochrane review of cholinergic drugs, including deanol, for tardive dyskinesia found the trials too few and too small to judge (Tammenmaa-Aho 2018). On the skin, a DMAE cream increased skin moisture in volunteers over 8 weeks, but so did the same cream without DMAE, and skin firmness did not change (Tadini 2009).

Safety: the sources here do not describe safety in detail. The sources here do not describe drug interactions.

DMAE half-life and time to peak

  • Half-lifeNot listed
  • Time to peak (Tmax)Not listed

We could not find a single published half-life or time to peak for DMAE that applies to a supplement dose, so we do not list one.

How to track DMAE in Dose Track

  1. Add DMAE as a custom compound. Start typing its name and Dose Track fills in the details from its research library for you to check, and it sits next to everything else you take.
  2. Log each dose when you take it so your history shows exactly what you took and when.
  3. Set reminders on your own schedule, whether that is daily, weekly or every few days.
  4. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

How Dose Track handles peptides · Reconstitution calculator · Half-life calculator

Centrophenoxine (Meclofenoxate)meclofenoxate, meclofenoxate hydrochloride Cholinecholine bitartrate, phosphatidylcholine Citicoline (CDP-Choline)CDP-choline, cytidine diphosphate choline Alpha-GPC (Choline Alfoscerate)L-alpha glycerylphosphorylcholine, choline alfoscerate

Frequently asked questions

What is the half-life of DMAE?+
We could not find a single published half-life or time to peak for DMAE that applies to a supplement dose, so we do not list one.
Does DMAE improve focus?+
Only one old trial supports it: in 1975, children with learning and behavior problems improved on some tests with deanol. There are no recent large trials.
Is DMAE the same as centrophenoxine?+
No. Centrophenoxine (meclofenoxate) is a related but separate drug. It is not FDA approved and is banned in sport by WADA.
Can I track DMAE in Dose Track?+
Yes. DMAE is in Dose Track's research library, so when you add it as a custom compound its details are filled in for you to check. You can then log each dose next to your other compounds, set reminders on your own schedule, and see your history next to your lab results. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

Sources

  1. Lewis JA, Young R. Deanol and methylphenidate in minimal brain dysfunction. Clin Pharmacol Ther. 1975;17(5):534-540.
  2. Tammenmaa-Aho I, et al. Cholinergic medication for antipsychotic-induced tardive dyskinesia. Cochrane Database Syst Rev. 2018;3(3):CD000207.
  3. Tadini KA, Campos PM. In vivo skin effects of a dimethylaminoethanol (DMAE) based formulation. Pharmazie. 2009;64(12):818-822.

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