Dihexa: What It Is, Animal Studies & Status | Dose Track
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Dihexa: what it is, animal studies and status

Amounts studied · Approval status · Half-life notes

What is dihexa?

Dihexa is a modified fragment of angiotensin IV, made by researchers at Washington State University to be taken by mouth and to cross into the brain. It has been studied only in cells and animals and is not approved for human use.

Also known as: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide.

Amounts studied

For dihexa, there is no approved product and no published human study, so there are no label strengths or studied human amounts.

Approval status and how it is used

Dihexa is not FDA approved, and we could not find any published study that gave it to people.

The two papers that introduced it reported reversal of memory deficits in rat models (McCoy 2013) and proposed that it works through hepatocyte growth factor (HGF) and its receptor, c-Met (Benoist 2014). In 2021 the journal published an expression of concern about both papers, and in 2025 it retracted the 2014 paper. A separate 2021 study (Sun) reported better spatial learning in a mouse model of Alzheimer's disease. Mouse and rat results often do not carry over to people.

Dihexa half-life and time to peak

  • Half-lifeNot listed
  • Time to peak (Tmax)Not listed

We could not find a published human half-life for this compound. Figures quoted online usually come from animal or cell studies, so we do not list one here.

How to track dihexa in Dose Track

  1. Add dihexa as a custom compound. Start typing its name and Dose Track fills in the details from its research library for you to check, and it sits next to everything else you take.
  2. Log each dose when you take it so your history shows exactly what you took and when.
  3. Set reminders on your own schedule, whether that is daily, weekly or every few days.
  4. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

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Frequently asked questions

What is the half-life of dihexa?+
We could not find a published human half-life for this compound. Figures quoted online usually come from animal or cell studies, so we do not list one here.
Has dihexa been tested in people?+
Not in any published study we could find. The research is in cells, rats and mice, and one of the two papers that introduced it was retracted in 2025.
Can I track dihexa in Dose Track?+
Yes. Dihexa is in Dose Track's research library, so when you add it as a custom compound its details are filled in for you to check. You can then log each dose next to your other compounds, set reminders on your own schedule, and see your history next to your lab results. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

Sources

  1. McCoy AT, et al. Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents. J Pharmacol Exp Ther. 2013;344(1):141-154 (expression of concern, 2021).
  2. Benoist CC, et al. The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system. J Pharmacol Exp Ther. 2014 (retracted 2025).
  3. Retraction notice to Benoist CC, et al. (2014). J Pharmacol Exp Ther. 2025;392(4):103567.
  4. Sun X, et al. AngIV-analog dihexa rescues cognitive impairment and recovers memory in the APP/PS1 mouse via the PI3K/AKT signaling pathway. Brain Sci. 2021;11(11):1487.

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