Artichoke extract is made from the globe artichoke (Cynara scolymus), a vegetable that is part of the Mediterranean diet, most often from its leaves. As a supplement it has been studied mainly for lowering cholesterol.
Also known as: Cynara scolymus, artichoke leaf extract, globe artichoke.
There is no intake value. The trials in the meta-analyses used different extracts and amounts, and the abstracts give no single amount.
It is sold in the US as a dietary supplement. Under the 1994 dietary supplement law (DSHEA), FDA does not approve dietary supplements before they are marketed, and the maker, not FDA, is responsible for safety and labeling.
What studies show: a 2018 meta-analysis of 9 trials (702 people) found that artichoke extract lowered total cholesterol by about 18 mg/dL, LDL cholesterol by about 15 mg/dL and triglycerides by about 9 mg/dL, with no change in HDL; the LDL drop was larger in people who started higher (Sahebkar 2018). A 2021 update of 14 studies found similar drops in total and LDL cholesterol (about 17 mg/dL each) and no change in HDL (Shahinfar 2021).
Safety: the sources here do not describe side effects or drug interactions.
We could not find a single published half-life or time to peak for artichoke extract that applies to a supplement dose, so we do not list one. Plant and bee products are mixtures of many compounds, so no single figure would describe them.
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