Armodafinil (Nuvigil): Half-Life, Label and Uses
[Prescription · Compound guide]

Armodafinil: half-life, strengths and approval status

Tablet strengths · Approval status · Half-life ~15 hours

Short answer: Armodafinil has a half-life of about 15 hours. Levels peak about 2 hours (fasted) after a dose. People vary, so treat these as estimates.

What is armodafinil?

Armodafinil is the R-enantiomer of modafinil, the longer-lasting of its two mirror-image forms. It is sold as Nuvigil and as generic tablets, approved to improve wakefulness in adults with excessive sleepiness from obstructive sleep apnea, narcolepsy or shift work disorder. It is a Schedule IV controlled substance.

Also known as: Nuvigil.

Tablet strengths

Nuvigil comes as 50 mg, 150 mg, 200 mg and 250 mg tablets.

Approval status and how it is used

The FDA Nuvigil label dose is 150 mg to 250 mg once a day in the morning for sleep apnea or narcolepsy, or 150 mg about 1 hour before the work shift for shift work disorder. In sleep apnea, the label says there is no consistent evidence that 250 mg works better than 150 mg. It is not approved for children.

Like modafinil, the label warns about serious rashes including Stevens-Johnson syndrome, allergic swelling (angioedema), psychiatric symptoms, and reduced effect of hormonal birth control. It is Schedule IV. See also modafinil.

Armodafinil half-life and time to peak

  • Half-lifeabout 15 hours
  • Time to peak (Tmax)about 2 hours (fasted)

The FDA Nuvigil label gives an apparent terminal half-life of about 15 hours and peak levels about 2 hours after a dose on an empty stomach; food can delay the peak by 2 to 4 hours. Steady state is reached within 7 days, at about 1.8 times the exposure of a single dose.

Numbers shown are taken from the source above. Half-life varies from person to person.

How to track armodafinil in Dose Track

  1. Add armodafinil as a custom compound. Start typing its name and Dose Track fills in the details from its research library for you to check, and it sits next to everything else you take.
  2. Log each tablet when you take it, including split or fractional tablets, so your history shows exactly what you took and when.
  3. Set reminders on your own schedule, whether that is daily, weekly or every few days.
  4. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

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Frequently asked questions

What is the half-life of armodafinil?+
The FDA Nuvigil label gives an apparent terminal half-life of about 15 hours and peak levels about 2 hours after a dose on an empty stomach; food can delay the peak by 2 to 4 hours. Steady state is reached within 7 days, at about 1.8 times the exposure of a single dose.
What is the difference between armodafinil and modafinil?+
Modafinil is a 50:50 mix of two mirror-image forms; armodafinil is only the R form, which the Provigil label says lasts about three times longer than the S form. Nuvigil (armodafinil) label doses are 150 to 250 mg; Provigil (modafinil) is 200 mg. Both labels give a half-life of about 15 hours.
Can I track armodafinil in Dose Track?+
Yes. Armodafinil is in Dose Track's research library, so when you add it as a custom compound its details are filled in for you to check. You can then log each tablet next to your other compounds, set reminders on your own schedule, and see your history next to your lab results. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.