Akkermansia muciniphila: Trials, Safety and Tracking
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Akkermansia muciniphila: half-life, strengths and approval status

Amounts studied · Approval status · Half-life notes

What is akkermansia?

Akkermansia muciniphila is a bacterium that lives in the gut lining, and people with obesity or type 2 diabetes tend to have less of it. It is sold as a probiotic, live or pasteurized (heat-killed), for metabolic health and weight, and has been tested in a few human trials.

Also known as: Akkermansia muciniphila, pasteurized Akkermansia, A. muciniphila.

Amounts studied

Akkermansia has no intake value or upper limit, and there is no NIH fact sheet for it. The 2019 pilot trial (Depommier) used 10 billion bacteria a day for 3 months. The European Food Safety Authority (EFSA 2021) concluded that 34 billion cells a day of pasteurized A. muciniphila is safe for adults, not including pregnant or breastfeeding women. These are study protocols, not a recommendation.

Approval status and how it is used

It is sold in the US as a dietary supplement. Under the 1994 dietary supplement law (DSHEA), FDA does not approve dietary supplements before they are marketed, and the maker, not FDA, is responsible for safety and labeling.

In a 3-month placebo-controlled pilot trial of 40 adults with overweight or obesity and insulin resistance, 32 of whom finished (Depommier 2019), live or pasteurized Akkermansia was safe and well tolerated. Pasteurized Akkermansia improved insulin sensitivity by about 29% and lowered insulin and total cholesterol compared with placebo; the drop in body weight (about 2.3 kg) was not statistically significant. In a 2026 trial of 90 adults (Mount), people who lost weight on an 8-week low-calorie diet and then took pasteurized Akkermansia for 24 weeks regained about 1.2 kg, compared with 3.2 kg on placebo. Some authors of that trial work for The Akkermansia Company.

EFSA reviewed pasteurized A. muciniphila as a novel food in the EU and found it safe at up to 34 billion cells a day for adults other than pregnant or breastfeeding women. No serious treatment-related side effects were reported in either trial, but the trials were small and short.

Akkermansia half-life and time to peak

  • Half-lifeNot listed
  • Time to peak (Tmax)Not listed

Akkermansia is a gut bacterium (live or pasteurized) that acts in the intestine, so there is no blood half-life to list.

How to track akkermansia in Dose Track

  1. Add akkermansia as a custom compound. Start typing its name and Dose Track fills in the details from its research library for you to check, and it sits next to everything else you take.
  2. Log each dose when you take it so your history shows exactly what you took and when.
  3. Set reminders on your own schedule, whether that is daily, weekly or every few days.
  4. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

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Frequently asked questions

What is the half-life of akkermansia?+
Akkermansia is a gut bacterium (live or pasteurized) that acts in the intestine, so there is no blood half-life to list.
Does Akkermansia help weight loss?+
Evidence is early. In a 2019 pilot trial, weight loss was not statistically significant, though insulin sensitivity improved. In a 2026 trial, people who had already lost weight regained about 2 kg less over 24 weeks than with placebo.
What is pasteurized Akkermansia?+
It is Akkermansia that has been heat-treated so the bacteria are no longer alive. In the 2019 pilot trial, the pasteurized form improved insulin sensitivity, and EFSA found it safe as a food ingredient for adults at up to 34 billion cells a day.
Can I track akkermansia in Dose Track?+
Yes. Akkermansia is in Dose Track's research library, so when you add it as a custom compound its details are filled in for you to check. You can then log each dose next to your other compounds, set reminders on your own schedule, and see your history next to your lab results. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

Sources

  1. Depommier C, et al. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nat Med. 2019;25(7):1096-1103.
  2. Mount S, et al. Pasteurized Akkermansia muciniphila MucT for weight loss maintenance in people with overweight and obesity: a controlled randomized trial. Nat Med. 2026;32(6):2107-2116.
  3. EFSA Panel on Nutrition, Novel Foods and Food Allergens. Safety of pasteurised Akkermansia muciniphila as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J. 2021;19(9):e06780.
  4. FDA. Questions and answers on dietary supplements.

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