Headaches and Dizziness on GLP-1 Medicines
[Answers · GLP-1 medicines]

Can GLP-1 medicines cause headaches or dizziness?

From FDA labels, public health agencies and published studies · Reviewed

Short answer: Yes, both are listed. In the Wegovy adult weight-loss trials, headache was reported by 14% versus 10% on placebo, and dizziness by 8% versus 4%. Zepbound reported dizziness in 4% to 5% versus 2%; headache is not in its table. The labels also report low blood pressure and fainting, often tied to fluid loss, and list headache and dizziness among the signs of low blood sugar.

What the labels report

Headache and dizziness in trials, from each US label (placebo in brackets)
Medicine and trialsHeadacheDizziness
Wegovy 2.4 mg, adults, weight reduction14% (10%)8% (4%)
Wegovy 7.2 mg trials9% on 7.2 mg, 8% on 2.4 mg (7%)6% on 7.2 mg, 5% on 2.4 mg (1%)
Wegovy 2.4 mg, ages 12 and up17% (16%)8% (3%)
Zepbound 5, 10 and 15 mg, weight reductionNot in the trial table4%, 5% and 4% (2%)
Ozempic, type 2 diabetesListed among reports after approvalListed among other side effects above 0.4%
Mounjaro, type 2 diabetesNot in the trial tableNot in the trial table

The Wegovy 7.2 mg dizziness figure includes dizziness on standing. A side effect missing from a table means it was not reported often enough, or not often enough above placebo, to be listed; it does not mean it cannot happen.

Low blood pressure and fainting

Two labels report blood pressure drops in their weight-loss trials:

  • Wegovy: low blood pressure (including on standing) in 1.3% versus 0.4% on placebo, and fainting (syncope) in 0.8% versus 0.2%. The label says some cases were related to stomach side effects and fluid loss, and that low blood pressure was more frequent in people also taking blood pressure medicines.
  • Zepbound: low blood pressure in 1.6% versus 0.1% on placebo; 2.2% in people on blood pressure medicines against 1.2% in those not on them. The label says it also occurred alongside stomach side effects and dehydration.

If you take blood pressure medicines, these are the figures to bring up with your prescriber. The blood pressure page covers what the GLP-1 trials found for blood pressure overall.

When headache or dizziness may be low blood sugar

The Ozempic, Wegovy, Mounjaro and Zepbound leaflets all list dizziness or light-headedness and headache among the signs of low blood sugar, alongside sweating, shakiness, blurred vision, fast heartbeat, hunger and confusion. They say the risk is higher when the medicine is used with insulin or a sulfonylurea. See low blood sugar on GLP-1 medicines for the trial rates.

Dizziness that needs help right away

The Mounjaro and Zepbound leaflets list "fainting or feeling dizzy" and "very rapid heartbeat" among the symptoms of a serious allergic reaction, together with swelling of the face, lips, tongue or throat, trouble breathing or swallowing, and severe rash or itching. They say to stop the medicine and get medical help right away if these happen.

For everyday headaches or light-headedness, useful notes are the day it happens relative to your dose, how much you drank, any vomiting or diarrhea, blood pressure or blood sugar readings if you take them, and other medicines. Dose Track keeps those notes next to each dose.

Read more on Dose Track: GLP-1s, testosterone and blood pressure · GLP-1 side effects week by week · Ozempic side effects · Wegovy side effects · Mounjaro side effects · Zepbound side effects

General education drawn from labels, public health agencies and published studies, not personal medical advice. Your prescriber, pharmacist and the label that came with your medicine are the final word. Questions for other users? Ask in the Dose Track community.

Frequently asked questions

Does Wegovy cause headaches?+
Headache is a listed side effect. In the adult weight-reduction trials it was reported by 14% on Wegovy 2.4 mg versus 10% on placebo.
Does Zepbound cause dizziness?+
Yes. In the weight-reduction trials, dizziness was reported by 4% to 5% depending on dose, against 2% on placebo. Low blood pressure was reported in 1.6% versus 0.1%.
Why might a GLP-1 make me dizzy?+
The labels link low blood pressure and fainting partly to fluid loss from stomach side effects, and list dizziness as a sign of low blood sugar, especially with insulin or a sulfonylurea.
When is dizziness on a GLP-1 an emergency?+
The Mounjaro and Zepbound leaflets say to stop and get medical help right away for fainting or dizziness with signs of a serious allergic reaction, such as face or throat swelling or trouble breathing.